My interest focuses on translating knowledge from basic research to clinical diagnosis and particularly, in developing and testing cutting edge technologies to incorporate advanced sequencing platforms, materials and techniques to improve the range of genetic and genomic services that can be offered to patients. One area of interest is to develop and apply cutting-edge technologies, such as next-generation sequencing and high resolution microarrays for clinical diagnosis of inherited cancer syndromes. My work also focuses on application and improvement of clinical exome sequencing as molecular genetics test for patients with complex phenotypes for which single gene tests or multi-gene panels are not clinically available. I am also interested in illustrating genetic and epigenetic changes in protein-coding and non-coding genes in cancers (especially, inherited cancers) and orphan genetic disease in order to understand the underlying pathological mechanisms, identifying new genetic and epigenetic markers for diagnosis and treatment, and developing more effective therapeutic strategies to treat patients.
MD, Dallian Medical University, China, 1999
PhD, Fudan University, China, 2005