Cost 
$525.00
TAT 
4 weeks
CPT Code 
81331
Test Code 
1104
Test Methods 
Methylation-specific MLPA
Specimen Types Accepted 
Blood
Saliva
Cultured Cells
Extracted DNA
Disorders 

We recommend methylation-specific (MS)-MLPA as the initial test for Angelman and Prader-Willi syndromes.  This testing will identify patients with abnormal methylation, large deletions and imprinting center deletions.  Those patients with abnormal methylation, but no deletion, should pursue UPD testing for UPD15.  Angelman syndrome patients with normal methylation should consider sequencing for UBE3A.