Cost 
$3,800.00
TAT 
6 weeks
CPT Code 
81407
Test Code 
5110
Test Methods 
Sequencing
Deletion/Duplication analysis
Specimen Types Accepted 
Blood
Saliva
Cultured Cells
Extracted DNA
Disorders 
Notes 
For patients with a history of lymphoma, cultured skin fibroblasts is the preferred specimen type (2 T-25 flasks);blood/saliva samples can be accepted only if patient has no history of blood involvement. Please contact the laboratory for more information.
Any gene in the Hereditary Lymphoma Panel can also be ordered individually. Please contact us directly for cost and CPT code information.
If sending saliva, 2 kits are required.
Variants within exons 1-5, 9 and 11-15 of the PMS2 gene may not be analyzed or reported due to homology issues.

Lymphomas are cancers originating from the lymphoid tissues, and can be divided into two broad categories, Hodgkin lymphoma and non-Hodgkin lymphoma, which can be differentiated by their cellular pathology. Hodgkin lymphoma (HL) is characterized by the presence of neoplastic binucleated B-cells called Reed-Steinberg cells. Exposure to Epstein Barr virus is associated with increased risk of HL. In addition, familial HL has also been described, and first degree relatives of a patient with HL having an increased risk of developing the condition. Non-Hodgkin lymphoma (NHL) is a diverse group of more than 50 types of lymphoma that arise from the lymphoid tissues but do not contain Reed-Steinberg cells, each with distinct morphological, cytogenetic, genetic and clinical features. Exposure to Epstein Barr virus and HIV are associated with increased risk of NHL; the contribution of other lifestyle factors and exposures remains unclear. Families with high rates of NHL have also been described, indicating a hereditary component in some cases. In addition, first degree relatives of patients with NHL have a 1.5-3 fold increased risk of developing the condition, again indicating a genetic component to disease susceptibility. Chronic lymphocytic leukemia (CLL) is considered a subtype of NHL. A 3- to 8.5-fold increased risk of CLL among first-degree relatives of probands has been reported.

Our Tier 1: Hereditary Lymphoma Panel includes sequencing and deletion/duplication analysis of the following 8 genes: CHEK2, KLHDC8B, NPAT, TP53, MLH1, MSH2, MSH6 and PMS2.

NOTE: For patients with a history of lymphoma, cultured skin fibroblasts is the preferred specimen type (2 T-25 flasks). Blood samples can be accepted only if the patient has no history of blood involvement. Please contact the laboratory for more information about specimen requirements.

Any gene in the Tier 1: Hereditary Lymphoma Panel can also be ordered individually. Please contact us directly for cost and CPT code information.