Approximately 1 in 8 couples who wish to have children experience infertility. Male factor infertility accounts for about half of these cases. An underlying genetic cause is suspected in 15% of men who are infertile. While chromosomal abnormalities (structural and numerical) account for a portion of these cases, monogenic disorders caused by pathogenic variants in both autosomal and sex chromosome genes are a common mechanism of male factor infertility.
The Male Infertility Panel utilizes next generation sequencing technology to detect sequence variants and deletions/duplication in over a hundred genes associated with male infertility. This test is appropriate for men who have already ruled out structural and numerical chromosomal abnormalities and deletions within the AZF region on the Y chromosome.
