Neurodegeneration with brain iron accumulation (NBIA) is a group of inherited neurologic disorders characterized by abnormal accumulation of iron in the basal ganglia (most often in the globus pallidus and/or substantia nigra). Generalized cerebral atrophy and cerebellar atrophy are frequently observed. The hallmark clinical manifestations of NBIA are progressive dystonia and dysarthria, spasticity, parkinsonism, neuropsychiatric abnormalities, and optic atrophy or retinal degeneration. Although cognitive decline occurs in some genetic types, more often cognition is relatively spared. Onset ranges from infancy to adulthood. Progression can be rapid or slow with long periods of stability. This panel includes sequence and deletion/duplication analysis of all the listed genes. 

6 weeks
CPT Code 
Test Code 
Test Methods 
Deletion/Duplication analysis
Specimen Types Accepted 
Cultured Cells
Extracted DNA
Additional Information 
Any gene in the NBIA Panel can also be ordered individually. Please contact us directly for cost and CPT code information.