Gastric cancers (GC) is the fifth most common malignancy in the world and the third leading cause of cancer death.  Most cases of gastric cancer are sporadic, occur at an old age (>65 years) and are associated with different environmental risk factors, including Helicobacter pylori infection, smoking, and a diet high in smoked and salted foods. About 1–3% of GCs can be considered hereditary due to germline pathogenic variants in cancer-predisposition genes. Gastric cancer predisposition has been linked to familial cancer syndromes, including Lynch syndrome, Peutz-Jeghers syndrome, Li-Fraumeni syndrome, familial adenomatous polyposis syndrome, and Cowden syndrome. Pathogenic variants in CDH1 represent the most common cause of hereditary diffuse gastric cancer syndrome. Germline pathogenic variants in KIT and PDGFRA have been reported in familial gastrointestinal stromal tumors. This test is specifically designed to detect germline pathogenic variants and is not appropriate for the detection of somatic variants in tumor tissue. The panel includes sequence and deletion/duplication analysis of all the listed genes. 

Institutional Price 
$2,500.00
TAT 
6 weeks
CPT Code 
81443
Test Code 
5121
Test Methods 
Sequencing
Deletion/Duplication analysis
Specimen Types Accepted 
Blood
Saliva
Buccal
Cultured Cells
Extracted DNA
Additional Information 
If sending saliva, 2 kits are required.
Any gene in the Hereditary Gastric Cancer Panel can also be ordered individually. Please contact us directly for cost and CPT code information.
Variants within exon 15 of the PMS2 gene may not be analyzed or reported due to homology issues. Due to high homology, the sensitivity of this assay may be reduced in exon 2 and exons 12-15 of PMS2.