Malignant Mesothelioma (MM) is an aggressive and highly fatal cancer associated exposure to asbestos. Only a small fraction of individuals exposed to asbestos have mesothelioma, suggesting that individuals with this type of cancer may have a genetic predisposition. Several studies have reported that up to 12% of patients with MM carry pathogenic germline variants in known cancer susceptibility genes Pathogenic variants in DNA repair genes may also increase susceptibility to MM in asbestos-exposed individuals. Genetic testing for germline pathogenic variants in a broad range of DNA repair and related genes has been recommended for mesothelioma patients at diagnosis, as the information obtained can be important for treatment, prognosis, and surveillance for additional cancers for patients, as well as for cancer screening and prevention for their families. This test is specifically designed to detect germline pathogenic variants and is not appropriate for the detection of somatic variants in tumor tissue. This panel includes sequence and deletion/duplication analysis of all the listed genes. 

6 weeks
CPT Code 
Test Code 
Test Methods 
Deletion/Duplication analysis
Specimen Types Accepted 
Cultured Cells
Extracted DNA
Additional Information 
3 to10 cc of blood in a purple top (EDTA) tube; or 2 T-25 flasks of cultured skin fibroblasts or DNA extracted from fibroblasts if the patient has a history of MDS/leukemia.
Any gene in the Mesothelioma Panel can also be ordered individually. Please contact us directly for cost and CPT code information.