Mesothelioma Panel

Malignant Mesothelioma (MM) is an aggressive and highly fatal cancer associated exposure to asbestos. Only a small fraction of individuals exposed to asbestos have mesothelioma, suggesting that individuals with this type of cancer may have a genetic predisposition. Several studies have reported that up to 12% of patients with MM carry pathogenic germline variants in known cancer susceptibility genes Pathogenic variants in DNA repair genes may also increase susceptibility to MM in asbestos-exposed individuals. Genetic testing for germline pathogenic variants in a broad range of DNA repair and related genes has been recommended for mesothelioma patients at diagnosis, as the information obtained can be important for treatment, prognosis, and surveillance for additional cancers for patients, as well as for cancer screening and prevention for their families. This test is specifically designed to detect germline pathogenic variants and is not appropriate for the detection of somatic variants in tumor tissue. This panel includes sequence and deletion/duplication analysis of all the listed genes.